ABSTRACT

This study determined the phytochemical screening, acute toxicity studies, antiinflammatory and anti urolithiatic of the aqueous and methanolic extracts of Tabernaemontana divaricata (carnation of India) belonging to the family Apocynaceae. Natural products which are of plant origin are found to be very useful and contain active constituents that cure or prevent many diseases. These natural products are believed to be safer when compared with synthetic drugs as they are less toxic with minimal side effects. Tabernaemontana divaricata (TD) is a shrub or small tree, usually glabrous, found in Konkan/Kanara regions of India and Bangladesh. The crude aqueous (AETD) and methanolic (METD) extracts of Tabernaemontana divaricata were tested for acute toxicity, anti-inflammatory activity by carrageenan induced edema and anti urolithiatic potential against ethylene glycol induced urolithiasis model. From growing evidences it was suggested the presence of phytoconstituents like carbohydrates, flavonoids, alkaloids, glycosides, steriods, saponins and tannins. Both the medicinal plant extracts were found effective against carrageenan induced edema and ethylene glycol induced urolithiasis. The results found in our current research might help the folklore botanical significance of the screened medicinal plant Tabernaemontana divaricata for the treatment of inflammation and urolithiasis. Key words: Tabernaemontana divaricate, Apocynaceae, Konkan, Kanara, acute toxicity, carrageenan, anti-inflammatory, ethylene glycol, urolithiasis
Publication date: 01/01/2020

https://ijbpas.com/pdf/2020/January/MS_IJBPAS_2019_4893.pdf

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https://doi.org/10.31032/IJBPAS/2020/9.1.4893