ABSTRACT

Neuroleptic drugs, essential in treating psychiatric disorders, often cause hormonal alterations by disrupting the hypothalamic-pituitary axis through their effects on dopaminergic and serotonergic pathways. These disturbances can lead to conditions such as hyperprolactinemia, thyroid dysfunction, metabolic syndrome, and alterations in sex and stress hormones, which may exacerbate psychiatric symptoms and impair physical health. Effective management requires a comprehensive understanding of these effects and strategies such as switching to atypical antipsychotics with lower endocrine impact, dose optimization, or adjunctive therapies like dopamine agonists or hormonal treatments. However, challenges persist due to underdiagnosis, limited clinical guidelines, and variability in individual responses. Advancing research to elucidate the mechanisms behind these alterations and develop targeted interventions is crucial. A multidisciplinary approach involving psychiatrists, endocrinologists, and researchers is vital to address these complexities, improve patient outcomes, and minimize the burden of neuroleptic-associated hormonal side effects. Keywords: Dopamine, Neuroleptic, psychiatric, endocrine etc.
Publication date: 01/04/2026

https://www.ijbpas.com/pdf/2026/April/MS_IJBPAS_2026_10058.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.4.10058