Neurodegenerative diseases pose a growing global health crisis, with no curative treatments
currently available due to the formidable blood-brain barrier limiting drug delivery.
Nanomedicine offers innovative solutions by utilizing Nano carriers like nanoparticles,
liposomes, and polymeric micelles to encapsulate therapeutics and enable brain targeting. This
review systematically examines emerging Nano carrier platforms for enhanced diagnosis and
therapy of neurodegenerative disorders. Lipid-based, polymeric, inorganic, and biomimetic
Nano carriers are discussed, highlighting their unique advantages in crossing the blood-brain
barrier, targeted delivery, sustained release, multimodal imaging, and neuroprotection. Novel
brain penetration strategies like inhibiting efflux transporters, polymer conjugation, and active
targeting ligands are explored. Applications in early detection, neural regeneration, and
combination therapies are presented. While challenges persist, the review provides insights into
potential breakthroughs leveraging biomimetic design, advanced targeting, gene editing, andtheranostic integration. Overall, nanomedicine represents a promising paradigm to
revolutionize neurodegenerative disease treatment.
Keywords: Alzheimer's disease, Huntington’s disease, nanomedicine, nanoparticles,
nanotechnology, and Parkinson's disease
Publication date: 01/04/2026
https://www.ijbpas.com/pdf/2026/April/MS_IJBPAS_2026_10065.pdf
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https://doi.org/10.31032/IJBPAS/2026/15.4.10065
