ABSTRACT

Objectives: Herbal extracts including ginger (Zingiber officinale), turmeric (Curcuma Longa) and Saffron (Crocus sativus) are known for their antibacterial activities. Streptococcus pyogenes is the predominant bacterial pathogen responsible for pharyngitis in both paediatric and adult populations. Over the years, the incidence of antibiotic resistance has been on the rise. Consequently, relying on a single herbal extract is inadequate for preventing bacterial infections. Additional studies are required to investigate the potential benefits of combining various herbal extracts with similar actions to identify bacteriostatic or bactericidal agent. This research aims to determine the MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) of Curcuma longa (Turmeric), Zingiber officinale (Ginger), and Crocus sativus (Saffron) against Streptococcus pyogenes. Methods: Different combinations of herbal extract test solutions were used in Mueller Hinton broth (Different combination of extracts with concentration about 11.00%, 14.10%, 17.20%, 20.30% and 23.50%) and positive control. Mueller-Hinton broth loaded with 1 ml bacterial suspension was used to determine the MIC (Minimum Inhibitory Concentration). The MBC (Minimum BactericidalConcentration) was estimated by culturing solutions from different extract dosages onto blood agar plates. Findings: The MIC (Minimum Inhibitory Concentration) for the combination of herbal extracts against Streptococcus pyogenes remains undetermined. The combined extracts exhibited a Minimum Bactericidal Concentration (MBC) of around 23.50%. This indicates that the combination of these herbal extracts has significant antibacterial activity against S. pyogenes. Novelty: Combination of herbal extracts including ginger (Zingiber officinale), turmeric (Curcuma Longa), and Saffron (Crocus sativus) showed antibacterial activity against S. pyogenes. Keywords: Herbal extracts, Curcuma Longa, Zingiber officinale, Crocus sativus, Streptococcus pyogenes, sore throat
Publication date: 01/04/2026

https://www.ijbpas.com/pdf/2026/April/MS_IJBPAS_2026_10071.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.4.10071