ABSTRACT

Glipizide, a BCS Class II antidiabetic drug, exhibits poor solubility and limited oral bioavailability, making it challenging to dissolve. Its rapid absorption requirement makes it suitable for Rapid Release Drug Delivery Systems. The purpose of this work was to utilize the solvent casting method to design and improve fast-dissolving oral films, guided by a 3² factorial design. The consequences of polymer composition and superdisintegrants on film appearance, disintegration time, and in vitro drug release were investigated. Solid dispersion demonstrated improved miscibility and faster drug release compared to the pure drug. The optimised formulation (F5) demonstrated a 93.0 % drug release and a disintegration time of 21 seconds. The films quality was validated by assessments of their physical attributes, folding durability, drug content homogeneity, surface pH, and thickness homogeneity. These findings indicate that Glipizide mouth- dissolving films formulated with HPMC K100 and sodium starch glycolate enhance bioavailability and therapeutic efficacy. Keywords: Fast dissolving oral film, Glipizide, 32 Factorial design, Diabetes Mellitus, bioavailability, first pass metabolism
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10106.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.5.10106