ABSTRACT

Diabetes Milletus is a metabolic condition by the common trait of chronic hyperglycemia. Hyperlipidemia is an abnormally elevated levels of any or all lipids or lipoproteins in the blood. An in-vitro study was carried for polyherbal extract to determine the combined effect of Anti-diabetic and Anti- Hyperlipidemic effect. The activity was confirmed using Alpha- glucosidase inhibition method and HMG- CoA reductase inhibition assay method. In the ?- Glucosidase Inhibition assay was performed on various concentration like 10, 20, 40, 80, 160, 320 (?g/ml). The effect of the extract at various concentrations were compared with standard Voglibose. The maximum inhibitory concentration IC 50 value of the sample (TEE) and the standard drug (Voglibose) was found to be 22.8 ?g/ml and 11.39 ?g/ml. The Hyperlipidemic aactivity was determined by HMG-CoA inhibition assay at various concentrations. The percentage inhibition of Polyherbal extract is compared with the standard drug Atorvastatin. The IC50 value of the sample was found to be 89.54 ?g/ml and the standard (Atorvastatin) was 20.46?g/ml, respectively. Overall, the study provides more information about the combination effects for the treatment of Diabetes milletus and Hyperlipidemia conditions, but more researches on animal studies will be more helpful to understand its therapeutic potential and safety profile. Keywords: Poly herbals, in-vitro anti-diabetic, anti-hyperlipidemic activity
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10108.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.5.10108