ABSTRACT

Push-Pull Osmotic Pumps (PPOP) have emerged as a promising drug delivery system for managing chronic diseases. These systems offer controlled, sustained, and targeted drug release, addressing the limitations of conventional delivery methods such as poor bioavailability, patient non-compliance, and side effects. PPOP employs a dual-chamber design, with one compartment containing the drug and the other an osmotic agent, facilitating precise and prolonged release through osmotic pressure. This review explores the principles, design, and mechanisms of PPOP, emphasizing its application in chronic disease management, including diabetes, cardiovascular diseases, and neurological disorders. The ability of PPOP to maintain consistent plasma drug concentrations enhances therapeutic outcomes and minimizes adverse effects. Additionally, recent advancements, such as incorporating nanoparticles and biodegradable materials, have further optimized PPOP for targeted delivery. This paper highlights the potential of PPOP in revolutionizing chronic disease treatment while identifying challenges and future research directions to maximize its clinical utility. Keywords: Push-Pull Osmotic Pumps, chronic disease management, bioavailability, dual-chamber
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10125.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.5.10125