ABSTRACT

Objective: Acid reflux, heartburn, indigestion, and gastro-oesophageal reflux disease (GERD) are treated with it. Additionally, stomach ulcers are prevented and treated with lansoprazole. Oral thin films breakdown quickly in the mouth along with the medication, and most of the medication enters the systemic circulation by way of the buccal mucosa, by-passing first pass metabolism. Materials and Methods: Utilising the solvent casting method, Lansoprazole fast dissolving oral thin films were created utilising a variety of film-forming ingredients, including polyethylene glycol 600 as plasticizer, saccharin as a sweetener, HPMC E15 as a polymer, and as a plasticize, citric acid as a saliva stimulating agent. Results: The evaluation criteria, which include drug content, folding endurance, thickness, and weight variation and disintegration time were performed for oral thin films. The formulations of oral fast dissolving film were optimized by employing Central composite design from Design Expert-13 Software. Lansoprazole oral thin films had a smooth surface, transparent, and were clear. Conclusion: Lansoprazole fast-dissolving oral thin films formulated and optimized by using central composite design were having good percentage cumulative drug release. Keywords: Lansoprazole, Solvent Casting method, Central composite design, Design Expert -13 and Oral thin films
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10148.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.5.10148