ABSTRACT

The main objective of the present research is a novel, rapid, precise and UV-Spectrophotometer method validation for lenvatinib. The analytical method was developed using orthophosphoric acid buffer and acetonitrile in the ratio 50:50 v/v. The absorbance was measured over a range 200- 400nm and wave length was found to be 212nm. The developed method obeyed beer's lamberts law showing good linearity over a range of 4-12 ?g/ml. The developed method was found to be accurate, precise. This shows a good recovery value having % RSD 1.297250 with in the acceptance criteria. And LOD was 1.65 ?g/ml LOQ was 5.0 ?g/ml. Thus, the evaluated method can be used routinely for quality control analysis of Lenvatinib drug. Additionally, the development of precise analytical methods for the quantification of lenvatinib in various media is crucial for ensuring its therapeutic efficacy and safety. Advances in UV-visible spectrophotometry provide an effective, economical, and robust approach for the analysis of lenvatinib, supporting its application in pharmaceutical formulations and enhancing quality control measures. These analytical techniques are essential for routine laboratory testing, contributing to improved patient outcomes and optimized drug development processes. Keywords: Lenvatinib, validation, Beer's lamberts law, anti-neoplastic agent, multi-kinase inhibitor
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10153.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.5.10153