ABSTRACT

Bilayer tablet offers controlled release that enhance drug action, efficacy and patient compliance, marking a substantial improvement in oral drug delivery system. Bilayer tablets allow continuous drug release over a long period of time by combining two different layers, usually with immediate release dose in one layer and sustained release dose in the other layer. Disadvantages of single layer or conventional tablets, such as chemical incompatibilities between the active ingredients, are addressed by this dual-layer formulation, which also improves bioavailability and lowers dosing frequency. The creation of both extended and immediate release formulations are made easier by control on bilayer tablet architecture which provides better release profile of active components. Innovative bilayer tablets are developed by number of pharmaceutical companies. To ensure cost effectiveness, the tablets are produced using modified tablet presses. In order to create controlled release and provide effective drug delivery, bilayer tablets are preferred. This review highlights the bilayer tablets with quality and GMP requirements, techniques of bilayer tablet production. Keywords: Bilayer Tablet, Active Pharmaceutical Ingredient, GMP Requirements, Regulatory Considerations
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10182.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.5.10182