ABSTRACT

The poor solubility of Rosuvastatin calcium affects its dissolution rate and, in turn, its bioavailability. The aim was to develop Rosuvastatin loaded nanoparticles and to evaluate it. The main aim of designing nanoparticles as a drug delivery system is due to reduction in particle size and thereby increases surface area, solubility and dissolution rate. The Rosuvastatin calcium nanoparticles were prepared by ionotropic gelation method. Chitosan, Gelatin and HPMC K4M were used as polymers in different concentration. FTIR studies revealed no interaction between drug and polymers. The prepared Rosuvastatin calcium nanoparticles were evaluated for Percentage yield, Entrapment efficiency and the in vitro release studies were performed. F3 formulation containing chitosan 150 mg shows the release of 98.09% in 8hrs was considered as optimum formulation. The optimized formulation (F3) was subjected to determine of particle size, polydispersity index, zeta potential and Scanning electron microscopy (SEM) studies. All the studies showed good results. The PDI for the optimized formulation of Rosuvastatin calcium nanoparticles is 0.402 which indicates a highly monodisperse sample with a very narrow size distribution. The optimized formulation of Rosuvastatin calcium nanoparticles (F3) has the zeta potential of -25.3 mV, the result suggest be that the optimized formulation was found to physically stable. The SEM images of Rosuvastatin calcium nanoparticles showed reduced crystallinity of drug. Keywords: Rosuvastatin calcium, Nanoparticles, Chitosan, Zeta potential and Ionotropic gelation method
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10203.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.5.10203