ABSTRACT

Streptococcus mutans is considered a major contributor to the development of dental caries and increased risk of developing dental caries later in life. The principal objective of this research is to design and develop xylitol lozenges that treat dental caries. Xylitol plays a major role in treating dental caries that act against Streptococcus mutans at different stages. The compatibility studies were performed using FT-IR and determining the MICs using the broth dilution method aids in the selection of the best formulation to reduce dental caries recurrence. In MIC 2% concentration of xylitol shows 66 % reduction of streptococcus mutans. Lozenges of varying concentrations were developed using starch syrup and tests were performed on the developed formulations. An anti-microbial assay was performed on the optimized formulation and the largest inhibitory zone against microorganisms was observed. Based on the findings of this study, it can be hypothesized that the developed formulation was active at lower concentrations and prolonged release by in-vitro drug release studies which reduce dental caries. Keywords: Xylitol, Lozenges, Streptococcus mutans, MIC, in vitro drug release
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10204.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2026/15.5.10204