ABSTRACT

Medicinal plants are naturally gifted with invaluable bioactive compounds which form the backbone of traditional medicines. Cisplatin is a highly effective chemotherapeutic agent; its clinical use is severely limited by serious side effects as nephrotoxicity. The present study was undertaken to evaluate the ethanolic extract of Tamarindus indica fruits pulp for its protective effects on cisplatin induced nephrotoxicity in rats. The Institutional Animal Ethics Committee (IAEC) approved the experimental protocol and the conditions in the animal house approved by Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA). Rats were divided into 5 groups; normal control, vehicle, nephroprotective drug (lipoic acid), EETI 200 mg/kg and 400 mg/kg p.o. Anti-oxidant enzymes such as superoxide dismutase and catalase were assayed, and EETI exhibited significantly improved CAT, GPx, MDA, and SOD levels. The levels of renal function markers such as serum creatinine, serum urea, blood urea nitrogen, serum urea, and serum uric acid levels also evaluated, and a significant retrieval was found in a dose-dependent fashion. There was a significant reduction in lipid peroxidation and rise in GSH levels with ethanolic extract of Tamarindus indica fruits treatment. These results suggest that the ethanolic extract of Tamarindus indica fruits may be useful in reducing the cisplatin induced nephrotoxicity. Keywords: Tamarindus indica, nephroprotective, cisplatin, serum blood urea nitrogen, superoxide dismutase
Publication date: 01/05/2026

https://www.ijbpas.com/pdf/2026/May/MS_IJBPAS_2026_10218.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.5.10218