ABSTRACT

Designing a highly effective class of innovative anti-diabetic agents possess a significant challenge in the field of pharmaceutical research and development. This research focuses on discovering a newer series of quinazoline derivatives. The synthetic process involves a couple of steps to prepare the quinazoline compound by reacting an amphoteric aromatic acid like anthranilic acid the desired chlorine compound benzoyl chloride in presence of highly flammable, weakly alkaline, heterocyclic organic compound pyridine, resulting in the formation of 2-phenyl-benzoxazine-4-one which is an intermediate compound which is further allowed to react with the hydrazine hydrate along with the pyridine and upon reflux for 3 hours will yield the desired quinazoline compound 3-amino-2-phenyl-quinazoline-4- one. Thin layer chromatography, IR spectroscopy, 1H NMR, 13C NMR confirmed the structure of the derivatives. Furthermore, these compounds are screened for their antimicrobial activity and anti- diabetic activity. The synthesized compounds such as Q1, Q2, QD1 have good anti-bacterial activity. Whereas Q5, and QD2 produced good anti-fungal activity and QD1 showed greater anti-diabetic activity than Q1. Keywords: Quinazoline derivatives, green synthesis, antimicrobial, spectroscopy, anti-diabetic activity
Publication date: 01/06/2026

https://www.ijbpas.com/pdf/2026/June/MS_IJBPAS_2026_10179.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.6.10179