ABSTRACT

Griseofulvin, a BCS Class II drug with poor aqueous solubility, is widely used to treat dermatophytic infections. To improve its solubility and topical delivery, Griseofulvin-loaded nanosponges were formulated and incorporated into a hydrogel. The nanosponges were prepared using the emulsion solvent diffusion method with ethyl cellulose, polyvinyl alcohol, and dichloromethane. The optimized nanosponge formulation (F4) was then incorporated into a hydrogel base using Carbopol 934, propylene glycol, and triethanolamine. Various physicochemical and in vitro evaluations confirmed the effectiveness and stability of the final formulation. Keywords: Griseofulvin; BCS Class II; Nanosponges; Hydrogel; Carbopol 934; Propylene glycol
Publication date: 01/06/2026

https://www.ijbpas.com/pdf/2026/June/MS_IJBPAS_2026_10208.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.6.10208