ABSTRACT

Nanosponges are a type of nanoparticle with a porous, sponge-like structure used for drug delivery and other applications. The aim of the present research work is to design, formulation and characterization of nanosponges loaded with sertraline hydrochloride. This work used varying quantities of the rate- retarding polymers polyvinyl alcohol (PVA) and ethyl cellulose (EC) in addition to surfactants, respectively, to construct and analyze nanosponges loaded with sertraline hydrochloride (NSG) using the solvent evaporation method. The final nanosponges were assessed for in vitro drug release, drug- polymer compatibility, particle size, incorporation efficiency, and percentage yield. Numerous nanoscopic channels and a porous structure were verified using Scanning Electron Microscopy (SEM). Sertraline hydrochloride was shown to be stable in the polymer mixture by Fourier Transform Infrared Spectroscopy (FTIR), which also revealed no drug-polymer interactions. Differential scanning calorimetry using DSC demonstrated the drug's involvement in the complexation with the nanosponges. Sertraline's mean particle size was also ascertained. The particle size was found to vary between 726 and 992 nm. Negative zeta potential values were attained to guarantee the nanosponges high stability. It was found that drug release from nanosponges might last up to 12 h. According to stability tests, the nanosponge demonstrated satisfactory stability for 90 days at 4 °C and 25 °C. Keywords: Sertraline hydrochloride, nanosponges, zeta potential, solvent evaporation, obsessive-compulsive disorder
Publication date: 01/06/2026

https://www.ijbpas.com/pdf/2026/June/MS_IJBPAS_2026_10228.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.6.10228