The non-invasive method of delivering medications to the circulatory system via the skin layers
is known as transdermal drug delivery. This review is emphasized on recent advances in the
formulation and evaluation of transdermal patches which done through extensive literature
survey i.e., Springer, Scopus, PubMed and Google Scholar.It includes drug reservoir,
membrane, drug, permeation enhancer, pressure-sensitive adhesives, backing films, and
plasticizers or solvents. Drug reaches the body through transappendageal route. It has various
advantages over other conventional drug delivery pathways i.e., avoiding first-pass
metabolism, extended drug release etc. Ionic medications cause issues in the formulation of
transdermal patches. The formulated transdermal patches are characterized with various
parameters i.e., Pre-formulation study, drug content, weight uniformity, percentage moisture
uptake, thickness, flatness, Water Vapor Transmission Rate (WVTR) Studies, moisture loss,
swellability, folding and tensile strength, in-vitro drug release, skin irritation, in vitro skin
penetration. In conclusion, transdermal patches are very promising in the cure and management
of numerous ailments with prolonged drug release and efficacy.
Keywords: Formulation, Evaluation, Transdermal Patches, Transappendageal Route, Review
Publication date: 01/06/2026
https://www.ijbpas.com/pdf/2026/June/MS_IJBPAS_2026_10230.pdf
Download PDF
https://doi.org/10.31032/IJBPAS/2026/15.6.10230
