ABSTRACT

The primary objective of this study was to develop and evaluate ethosomal formulations incorporating Millingtonia hortensis leaf extract. Ethosomes were prepared using the cold method, with each formulation containing 30 mg of drug and varying proportions of ethanol, propylene glycol, and soy lecithin in 5 mL of distilled water. The ethosomes were characterized using Fourier Transform Infrared Spectroscopy (FTIR), zeta potential analysis, particle size determination, entrapment efficiency evaluation, and drug release studies. An ethosomal gel was subsequently formulated using the dispersion technique. The gel was assessed for drug content, in vitro drug release, and pH.The optimized B9 formulation demonstrated a particle size of 226.54 nm, a zeta potential of - 24.60 mV, and a pH range of 4–6. This optimized formulation exhibited enhanced penetration properties, indicating its potential as a promising candidate for improving bioavailability. Keywords: Millingtonia hortensis, Ethosome, Cold method, Evaluation, Penetration, Soy lecithin
Publication date: 01/06/2026

https://www.ijbpas.com/pdf/2026/June/MS_IJBPAS_2026_10238.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.6.10238