An ulcer refers to a disruption or break in the continuity of a body membrane, which impairs the
normal function of the affected organ. Ulcers can occur in various forms, including arterial, genital,
venous, peptic, and mouth ulcers. A mouth ulcer, also known as aphthous stomatitis, is
characterized by the recurrent formation of painful ulcers on the non-keratinized mucous
membranes of the oral cavity. These ulcers are typically found on the inner cheeks, gums, lips, and
occasionally on the tongue. Mouth ulcers are often inflammatory and can cause significant pain,
leading to difficulties in speaking or brushing teeth.
In the market, many gel formulations containing herbal extracts or other natural ingredients are
available for the treatment of mouth ulcers. Traditional oral gel formulations are widely used, but
more advanced systems, such as mucoadhesive drug delivery systems, are becoming increasingly
popular. These novel systems have gained attention due to their ability to deliver drugs directly
through mucosal surfaces like those found in the eyes, nose, lungs, vagina, and buccal cavity.
Mucoadhesive buccal patches, in particular, offer several advantages over conventional oral
dosage forms. They provide a prolonged residence time on the mucosal surface, allowing for longerlocal action and improving patient compliance. Moreover, these patches can be easily removed if
any adverse reactions or toxicity occur, making them a safer and more convenient option for self-
medication the dosage form from the buccal cavity. In case of mouth ulcers, application of
mucoadhesive patches can protect the disrupted mucosa from its contact with spicy food and
increase patient compliance.
Keywords: Mucodhesive Buccal Patch, Mouth Ulcers, Aphthous Stomatitis
Publication date: 01/06/2026
https://www.ijbpas.com/pdf/2026/June/MS_IJBPAS_2026_10244.pdf
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https://doi.org/10.31032/IJBPAS/2026/15.6.10244
