ABSTRACT

Acne is a chronic inflammatory state. It occurs in the skin due to acne vulgaris. The number of antibiotics resistant to acne and bacterial strains is increasing daily. Herbal anti-acne cream is the best and safest method to prevent from antibiotic resistant. In the present study, we formulated and evaluated an anti-acne herbal cream using methanolic extract of Tagetes erecta (Marigold) flower petals. Tagetes erecta contains an abundant amount of flavonoids that are responsible for showing anti-microbial activity. The antimicrobial activity of methanolic extract in different concentrations (12.5%, 50%, 100% w/v) was investigated against Streptococcus aureus and Escherichia coli using the agar well diffusion method. The results of various concentration such as 12.5%, 50% and 100% w/v extracts of Tagetes erecta showed good antimicrobial activity. It inhibits bacterial growth which was confirmed by their zone of inhibition 22mm, 25mm and 100mm respectively. The research emphasizes flavonoids showing the anti-acne effect of extracts, significantly affecting the gram-positive and gram- negative bacteria. The present work confirmed the successful antimicrobial activity of Tagetes erecta flower petals. So, three batches (F1, and F3) were formulated using the o/w type emulsion method. Furthermore, the evaluation of the herbal cream was carried out based on physical appearance, pH, viscosity, homogeneity, irritancy testing, dye test, spreadability and wetness. F3 formulation showed the best results. Keywords: Tagetes erecta, Antimicrobial activity, Anti-acne herbal cream, Acne vulgaris, Well diffusion method
Publication date: 01/06/2026

https://www.ijbpas.com/pdf/2026/June/MS_IJBPAS_2026_10251.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.6.10251