ABSTRACT

Shilajit, a sticky black exudate of herbomineral origin, is commonly found in mountainous regions and generally consists of a complex mixture of organic humic substances and traces of plant and microbial metabolites. Humic acid and fulvic acid which are important constituents of Shilajit are responsible for its various pharmacological actions. Shilajit has been used popularly and safely as a rejuvenator and adaptogen for millennia as an integral part of traditional systems of medicine globally. The current research aims to improve the therapeutic efficacy of Shilajit for cardiovascular health by formulating the drug as zinc nanoparticles while simultaneously working to conserve natural mineral resources by significantly decreasing the dose required using this approach. The formulation was optimised using QbD and characterized using parameters such as entrapment efficiency, particle size, and zeta potential. In vitro diffusion studies, chorioallantoic membrane assay and trypan blue test for cell viability indicated better biological activity of the nanoparticles as compared to the extract thus indicating a significantly improved activity. When traditional medicinal agents such as Shilajit are combined with modern formulation techniques, a significant improvement is seen in its activity. Hence there is great potential for the development of novel drug delivery systems for traditional medicinal systems Keywords: Shilajit, fulvic acid, zinc nanoparticles, cardioprotective, anti-oxidant, QbD
Publication date: 01/07/2026

https://www.ijbpas.com/pdf/2026/July/MS_IJBPAS_2026_10241.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.7.10241