ABSTRACT

The primary objective of this study was to enhance the solubility of Ramipril using the pastillation technique. Improving the solubility of Ramipril is crucial for increasing its bioavailability and therapeutic efficacy. The study aimed to formulate and evaluate the pastilles of Ramipril and compare their solubility and dissolution profiles with that of the pure drug and marketed formulations. The pastillation technique was employed to enhance the solubility of Ramipril. Various batches of pastilles were prepared using different concentrations of excipients. The drug and excipient mixtures were heated, melted, and then cooled to form pastilles. PEG 6000 and gelucire 50/13 use as polymer for preparation of pastilles. The prepared pastilles were evaluated for their physicochemical properties, including solubility, drug content, and dissolution rate. Techniques such as Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM) were used to characterize thepastilles and study the drug-excipient interactions. The study demonstrated that the pastillation technique significantly improved the solubility and dissolution rate of Ramipril. The optimized batch of pastilles showed a higher solubility and faster drug release compared to the pure drug and marketed formulations. FTIR, DSC, and SEM analyses confirmed the formation of a stable drug- excipient complex with no significant interactions that could affect the drug's stability. The drug release from the optimized pastilles followed a zero-order kinetics model, indicating a controlled and sustained release profile. The pastillation technique is an effective method for enhancing the solubility of Ramipril. The formulated pastilles showed improved solubility, higher drug content, and a better dissolution profile compared to the pure drug and marketed formulations. This technique can be potentially applied to other poorly soluble drugs to enhance their bioavailability and therapeutic efficacy. Keywords: Bioavailability, Drug Release, DSC, FTIR, Pastillation Technique, Ramipril, SEM, Solubility Enhancement, Zero-order Kinetics
Publication date: 01/07/2026

https://www.ijbpas.com/pdf/2026/July/MS_IJBPAS_2026_10299.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.7.10299