ABSTRACT

The present study aimed to formulate and optimize gastro-retentive floating tablets of Albuterol for sustained drug release and improved gastric retention. Albuterol, a ?2-agonist used in the treatment of asthma and chronic obstructive pulmonary disease, has a short half-life and requires frequent dosing. To overcome this limitation, floating tablets were prepared by direct compression using varying concentrations of Xanthan gum (X1), Sodium alginate (X2), and Sodium bicarbonate (X3) as per a 2³ full factorial design. Eight formulations (F1–F8) were evaluated for pre- and post-compression parameters, floating lag time, total floating duration, and in-vitro drug release over 11 hours. Drug release kinetics were analyzed using Zero-order, First-order, Higuchi, and Korsmeyer–Peppas models. The optimized formulation showed controlled release, acceptable hardness, friability, and short floating lag time with prolonged buoyancy. Statistical analysis through Design-Expert software revealed significant main and interaction effects among variables, and an optimized batch was identified using desirability function. The study concluded that gastro-retentive drug delivery of Albuterol using natural polymers is a promising approach to enhance therapeutic efficacy by prolonging gastric residence and reducing dosing frequency. Keywords: Albuterol; Xanthan gum; Sodium alginate; Sodium bicarbonate; Natural Polymers
Publication date: 01/07/2026

https://www.ijbpas.com/pdf/2026/July/MS_IJBPAS_2026_10317.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.7.10317