ABSTRACT

The quantification of omeprazole in pharmaceutical formulations remains a critical aspect of quality control in the pharmaceutical industry. This review focuses on the review of analytical methodologies in omeprazole determination and their development in terms of the dosage forms. This phenomenon makes analytical methods involving omeprazole quite unique, to the extent that a typical benzimidazole derivative, an antiproton pump drug, is highly susceptible to light, heat, and acidic environments. The paper gives a detail overview of both traditional and contemporary techniques, both simple (UV spectrophotometry) and advanced (hyphenated techniques such as LC-MS/MS). In particular, the analysis of combination formulations of omeprazole with antibiotics or NSAIDs is discussed separately due to their specific demands in the matter. The discussion critically discusses each method with respect to the principles of each technique, parameters of the methods, aspects of validation and uses in practice. Recent technological developments are brought to attention especially use of green analytical methods and small systems. The comparison of different techniques against each other in terms of these factors, sensitivity, cost, time to conduct analysis, effects on the environment are provided. The paper ends by looking at future trends especially in pharmaceutical analysis with the involvement of artificial intelligence and automation. This detailed review is a useful tool to analyze chemists and pharmaceutical scientists who analyze and develop methods of quality control of omeprazole. Keywords: Omeprazole, Analytical techniques, Chromatography, Spectrophotometry, LC-MS
Publication date: 01/07/2026

https://www.ijbpas.com/pdf/2026/July/MS_IJBPAS_2026_10342.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.7.10342