ABSTRACT

Liquisolid approach, a newer formulation strategy is applied for enhancing the dissolution rate of drugs that are sparingly aqueous soluble. New excipient allows the formulation scientists to achieve specific objectives in innovative areas of drug formulation. The current study was aimed at assessing the potential of honey as a non-volatile vehicle in creating liquisolid tablets of ondansetron. Six formulations of ondansetron tablets with uniform weight were prepared in the present work. Two non-volatile solvents, namely propylene glycol, a commonly used solvent and honey, a novel alternative were employed. A constant liquid load factor was maintained for all the formulations and compressed to get 250 mg tablets. The flow property of pre-compression blends was evaluated. All formulations underwent drug release studies. The obtained dissolution profiles were compared with formulation F1 based on similarity factor (f2), the model-independent approach. Both the bulk drug and the optimized formulation were characterized by FTIR evaluation. Assay, weight variation, friability, disintegration time and hardness results were acceptable for all the tablet batches prepared. The weight variation is less than 5% and the drug content values were within the range of 100 ± 10%, prescribed for ondansetron drug in IP. Ondansetron tablets containing honey showed similar dissolution rates with that of propyleneglycol containing tablets. Formulation F6 containing honey and croscarmellose sodium at 8% level was found to show highest drug release rate and can be considered as the optimum formulation. Based on the FTIR studies ondansetron was found to be compatible with all the excipients employed in this study. Finally, honey is found to be an alternative novel non-volatile vehicle for the formulation of ondansetron liquisolid tablets. Keywords: Liquisolid tablets, Ondansetron, Honey, FTIR studies, Dissolution studies
Publication date: 01/07/2026

https://www.ijbpas.com/pdf/2026/July/MS_IJBPAS_2026_10352.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2026/15.7.10352