ABSTRACT

The goal of the current study is to create floating famotidine tablets employing a variety of excipients, including DCP, HPMC K4M, and HPMC K100. The goal is to increase patient compliance and treatment effectiveness for illnesses related to acid reflux. tablets made using the melt-solidification method. The formulation was designed to give regulated release of famotidine and prolong gastric resistance. The tablets were able to float in the stomach because sodium bicarbonate produced carbon dioxide. A factor in the persistent release was HPMC K4M. The impact of HPMC's viscosity grades and polymer concentration on the medication release profile was assessed. The drug release profile was not significantly impacted by changing the viscosity grade of HPMC from K4M to K100MCR. The tablets' floating behaviour, drug release, and other characteristics, such as weight fluctuation, hardness, friability, and homogeneity of drug content, were assessed. Keywords: HPMC K 4 M, Tablet, HPMC K 100, Gastric Resistance
Publication date: 01/08/2026

https://www.ijbpas.com/pdf/2026/August/MS_IJBPAS_2026_10331.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.8.10331