ABSTRACT

This review critically examines the analytical methodologies developed for the determination of methimazole (MMZ) across pharmaceutical, biological, and food matrices. We summarize classical approaches—such as UV-Visible spectrophotometry, HPLC-UV, and TLC—and compare them with advanced techniques including molecularly imprinted polymer solid-phase extraction, LC-MS/MS, and surface-enhanced Raman spectroscopy (SERS). Key performance metrics (linearity, limits of detection and quantification, precision) are tabulated to facilitate direct comparison and these methods offer advantages like low solvent usage, improved selectivity, and better analyte enrichment. Finally, we discuss green-chemistry trends and propose future research directions aimed at simplifying sample preparation, reducing solvent consumption, and enhancing method sensitivity. Keywords: Electrochemical detection, HPLC-UV detection, LC-MS/MS, Solid-phase extraction, Methimazole analysis, Molecular characterization, Therapeutic drug profiling, UV-Visible spectrophotometry
Publication date: 01/08/2026

https://www.ijbpas.com/pdf/2026/August/MS_IJBPAS_2026_10332.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.8.10332