ABSTRACT

The complex endocrinology disorder known as PCOS, which stands for polycystic ovarian syndrome impacts an enormous proportion of reproductive-age women. A variety of clinical symptoms, including as irregular menstruation, anovulation, infertility, hyperandrogenism, and Metabolic conditions including adiposis and type 2 diabetes are caused by hormonal imbalances, insulin resistance (IR), and ovarian dysfunction. A hallmark of PCOS, impaired insulin sensitivity plays a significant part of the pathophysiology of the condition and its related consequences, such as metabolic disorders, endometrial cancer, and infertility. The review highlights the significance of early detection and treatment to reduce PCOS's long- term health hazards. It concludes by emphasizing the need for personalized, multidisciplinary treatment strategies and further research to fully elucidate PCOS pathophysiology and develop targeted therapies. Keywords: Insulin resistance (IR), Hyperinsulinemia, Ovarian Dysfunction, Endometrial Cancer
Publication date: 01/08/2026

https://www.ijbpas.com/pdf/2026/August/MS_IJBPAS_2026_10371.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.8.10371