Medically compromised patients increasingly seek prosthodontic care due to longer lifespan,
improved medical management of systemic diseases, and growing awareness of oral rehabilitation.
Systemic diseases influence salivary gland function, mucosal tolerance, bone metabolism,
osseointegration, neuromuscular control, bleeding tendency, and healing capacity — all of which
impact prosthodontic prognosis. This narrative review examines prosthodontic considerations and
treatment modifications for cardiovascular diseases, anticoagulant therapy, diabetes mellitus, thyroid
and adrenal disorders, chronic obstructive pulmonary disease (COPD), asthma, tuberculosis,
Parkinson’s disease, osteoporosis, Paget’s disease, fibrous dysplasia, cancer undergoing
chemotherapy and radiotherapy, osteoradionecrosis, and implants in irradiated bone. Evidence-based
clinical recommendations encompass modifications to impression techniques, the utilisation of soft
liners, saliva substitutes, stress-reduction protocols, recall scheduling, and interprofessional
communication. Safe prosthodontic rehabilitation is possible with the right evaluation and changes.
Keywords: Prosthodontic management, medically compromised patients, dental management,
systemic disease, and prosthodontic considerations
Publication date: 01/08/2026
https://www.ijbpas.com/pdf/2026/August/MS_IJBPAS_2026_10424.pdf
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https://doi.org/10.31032/IJBPAS/2026/15.8.10424
