ABSTRACT

Yashada bhasma, a traditional Ayurvedic metal-based preparation of zinc oxide nanoparticles used in wound care and diverse health conditions. Similarly in contemporary science, green-synthesized zinc oxide nanoparticles (GSZnO NP) are recognized for their antimicrobial activity. As both comprise zinc oxide nano particles, the present study aimed to compare their antimicrobial efficacy, employing yashada bhasma prepared via the vanaspatimarita (Calcination using herbal drug) method with kumari swarasa (aloe vera juice) as a bhavana dravya, and GSZnO NP synthesized using aloe vera aqueous extract. This study employed minimum inhibition concentration (MIC) assays and agar disc diffusion methods to compare the anti-microbial effectiveness of both formulations at two different doses (6mg and 125mg) against common pathogens: staphylococcus aureus, pseudomonas aeruginosa, escherichia coli, and candida albicans. Results indicated that GSZnO NP showed higher sensitivity to staphylococcus aureus followed by pseudomonas aeruginosa and e.coli at lower concentration compared to yashada bhasma, whereas yashada bhasma exhibited greater effectiveness against candida albicans at two different doses. These findings highlight the potential of yashada bhasma in treating fungal infections and the suitability of GSZnO NP for bacterial diseases. The study underscores the integration of traditional Ayurvedic medicine with modern nanotechnology to address infectious pathogens, suggesting avenues for further research and clinical applications in healthcare. Keywords: Yashada bhasma, GSZnO NP, MIC, Agar disc diffusion, Anti-microbial
Publication date: 01/09/2026

https://www.ijbpas.com/pdf/2026/September/MS_IJBPAS_2026_9828.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.9.9828