ABSTRACT

Recurrent, unprovoked seizures are hallmark of epilepsy, a chronic neurological condition that is frequently linked to cognitive and neurobehavioral comorbidities including depression and memory loss. Aim of current study was to assess antiepileptic effects of Rutin, a naturally occurring flavonoid, against seizures in Swiss albino mice caused by pentylenetetrazole (PTZ). For predetermined treatment period of 14 days prior to PTZ challenge, Rutin was given orally at two dosage levels, 50 mg/kg (low dose) and 100 mg/kg (high dose). Modified Racine's scale was used to gauge the intensity of seizures, and Novel Object Recognition Test (NORT), Forced Swim Test (FST) were used to gauge cognitive and emotional behaviors, respectively. Findings showed that Rutin at 100 mg/kg considerably reduced the intensity of seizures and had an antiepileptic effect similar to that of standard valproic acid (VPA). Additionally, in PTZ- induced mice, high-dose Rutin significantly enhanced memory function and decreased depressive-like behavior, whereas the low-dose group just slightly benefited. According to these results, Rutin at a high dose of 100 mg/kg may be a viable option for treating epilepsy and its associated comorbidities. Keywords: Pentylenetetrazole (PTZ), Seizures, Rutin, Valproic acid (VPA), Modified racine’s scale
Publication date: 01/09/2026

https://www.ijbpas.com/pdf/2026/September/MS_IJBPAS_2026_10435.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.9.10435