ABSTRACT

The skin's barrier function presents a significant obstacle for simple, non-invasive drug delivery methods. Conventional liposomes and niosomes are not well-suited for transdermal delivery because they struggle to penetrate the skin effectively, are prone to instability and drug leakage, and often clump and merge together. Transfersomes, designed specifically to overcome these limitations, offer a promising alternative. Transfersomes, however, are specifically engineered to address these shortcomings. These artificially created vesicles are designed to emulate the behavior of natural cell vesicles or cells undergoing exocytosis. The ultra-deformable lipid membranes of Transfersomes allow them to potentially overcome the challenges of transdermal delivery. This paper provides a comprehensive exploration of Transfersomes, covering their composition, mechanism of action, advantages, disadvantages, preparation, characterization, and diverse applications in pharmaceuticals and biomedicine. Furthermore, the paper discusses successful research in transferosomal delivery and examples of marketed products, highlighting their potential to revolutionize targeted therapies by improving drug delivery across the skin. Keywords: transferosomes, TDDS, Film hydration technique, Phospholipids, lipid based formulations
Publication date: 01/09/2026

https://www.ijbpas.com/pdf/2026/September/MS_IJBPAS_2026_10477.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.9.10477