ABSTRACT

Chalcone derivatives have attracted considerable interest due to their diverse pharmacological properties, particularly their antimicrobial potential. In the present study, a novel substituted phenyl- trimethoxy substituted chalcone derivatives were synthesized by green synthesis techniques and evaluated for its antibacterial activity against selected Gram-positive and Gram-negative bacterial strains. The compounds were synthesized through a Claisen–Schmidt condensation reaction and subsequently characterized using spectral techniques to confirm its chemical structure and functional groups. Spectral analysis indicated the successful formation of the chalcones framework along with the presence of the intended substituted phenyl trimethoxy chalcone derivatives. The antibacterial activity of the synthesized compound was assessed using an agar diffusion method against representative Gram-positive and Gram-negative bacterial strains. The results demonstrated that the compounds exhibited appreciable antibacterial activity, producing distinct zones of inhibition against the tested organisms. The observed activity was comparable to that of the standard antibacterial drug used in the study. The findings indicate that the substituted phenyl-trimethoxy chalcone derivatives synthesized via a green synthetic approach exhibited high purity and good percentage yield, and may serve as promising lead molecules for the development of novel antibacterial agents. Further studies involving structural modification and detailed biological evaluation are warranted to enhance their therapeutic potential. Keywords: Chalcones, Claisen–Schmidt condensation, Acetophenone, Benzaldehyde
Publication date: 01/11/2026

https://www.ijbpas.com/pdf/2026/November/MS_IJBPAS_2026_10570.pdf

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https://doi.org/10.31032/IJBPAS/2026/15.11.10570