Because it makes it possible to create customized medications, intricate geometries, and programmed drug
release systems, three-dimensional (3D) printing has become a game-changing technology in the
pharmaceutical sciences. Customized pharmacokinetics and patient-specific dosing are frequently not
possible with conventional dose forms. A synergistic platform that combines precise manufacturing with
increased solubility, targeting, controlled release, and bioavailability is provided by the combination of 3D
printed dosage forms and nanoparticle-based drug delivery. Tablets, films, microneedles, implants, and
scaffolds made by additive manufacturing can incorporate nanoparticles such as polymeric nanoparticles,
liposomes, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and metallic
nanoparticles. The foundations of pharmaceutical 3D printing technologies, the function of nanoparticles
in sophisticated formulations, comparative examples of medications created using printed systems loaded
with nanoparticles, evaluation techniques, therapeutic applications, benefits, drawbacks, and future
prospects are all summarized in this review. The integration of nanotechnology and 3D printing is a
significant step toward next-generation smart dosage forms, on-demand production, and precision
medicine.
Keywords: 3D Printing, Nanoparticles, Drug Delivery System, Personalized Medicine, Controlled
Release, Novel Dosage Forms, Printlets, Nanotechnology
Publication date: 01/11/2026
https://www.ijbpas.com/pdf/2026/November/MS_IJBPAS_2026_10619.pdf
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https://doi.org/10.31032/IJBPAS/2026/15.11.10619
